Viral Hepatitis B Screening among Asymptomatic Patients of Liver Pathology in a Secondary Health-care Facility in Nigeria

Background:HBVinfectionisaseriousailmentwhichdamagestheliveryetnotwellknownandhencenotgivenadequateattention.Manyareinfectedbutarenotawarebecausetheydonotmanifestanysignandsymptom.Aim:ThepurposeofthisstudywasthereforetoevaluatetheprevalenceofHBsAgamongasymptomatichospitalattendees.StudyDesign:Acrosssectionalstudy.PlaceandDurationofStudy:StMary’sCatholicHospital,Ibadan,Nigeria,betweenNovember2017andAugust2018Methodology:1328consecutivepatientswhoattendedthehospitalwereenrolledintothisstudyafterobtainingtheirconsent.TheirbloodsampleswereasepticallycollectedandassayedforHBsAgusingconventionalmethod.Results:Atotalof1,328participantswereenrolled,outofwhich421(31.7%)weremaleand907(68.3%)werefemalewithagenderratioof1:2.2-maletofemale.5.9%(25/421)ofthemalestestedpositivetoHBsAgwhile5.4%(49/907)ofthefemalestestedpositivetoHBsAg(p=0.692).Oftheoverall1328individualsscreened,5.6%testedpositivetoHBsAg.TheagegroupwiththehighestprevalenceofHBsAgwerethosebetween51and60yearswith13.1%followedby41-50years(7.2%)while>70yearshadthelowestprevalence.Conclusion:ThisstudyshowedthatHBsAginfectionishighamongasymptomatichospitalattendeesinIbadan,Nigeria.Morepublicsensitizationandawarenessprogrammesarestronglyadvocatedfor

Knowledge, Attitude And Practice Of Hepatitis-B Vaccination Among The Medical Faculty Of A Teaching Hospital, Aurangabad

Infection with hepatitis B virus can cause both acute and chronic liver disease. The virus can be transmitted through contact with blood or other body fluids of an infected person. All over the world, approximately 257 million people have been infected with hepatitis B virus (HBV). In 2015, hepatitis B resulted in 887000 deaths, mostly from HBV– related cirrhosis or Hepatocellular Carcinoma. In present study we assess the Knowledge, Attitude and Practice of Hepatitis B Vaccination among the medical faculty of MGM Medical College and Hospital, Aurangabad, Maharashtra. The present cross sectional Observational study among the medical faculty of MGM Medical College, Aurangabad, India. The study was conducted during 1st Jan 2018 to 31st Oct. 2018. In the present study 160 medical faculties were enrolled. Apre-structured questionnaire was developed consisting of the participant's socio-demographic characteristics, vaccination status, barriers for immunization and basic awareness regarding HBVtransmission. Out of 160 participants, 86 (53.7%) were males and 74 (46.2%) were females. Maximum participants were from age group of 31-40 years (45.6%).134 (83.7%) participants had been vaccinated against HBV. Out of total 160 participants, 92 (57.5%) had good awareness score of Hepatitis B vaccination and only 3 (1.9%) participants had poor awareness. The continued efforts are needed to increase awareness and vaccination coverage among medical professionals. The importance of doing anti Hbs titre after complete vaccination needs to be imposed upon the medical professionals for protection against accidental needle stick injuries.

Observation of clinical efficacy of silybin combined with nucleotides in the treatment of viral hepatitis with nonalcoholic fatty liver disease / 中国基层医药

Objective To evaluate the clinical efficacy of silybin combined with nucleotides in the treatment of viral hepatitis associated with nonalcoholic fatty liver disease (NAFLD).Methods 88 viral hepatitis patients with NAFLD were randomly selected into the clinical research,and they were divided into groups according to the order of treatment.Among them 44 cases of single number were the control group treated with nucleoside(acid) drugs,44 cases of double number were the observation group treated with silibinincombined silybin combined with nucleoside(acid).The therapeutic effect after the end of the course of treatment were was evaluated.Results The effective rate in the observation group was 90.91％,which that in the control group was 70.45％,the difference was statistically significant (x2 =8.87,P ＜ 0.05).The ALT,AST,r-GGT after treatment of the observation group were (37.14 ± 3.56) U/L,(30.45 ±3.35) U/L,(51.65 ± 3.46) U/L,which were significantly reduced than before treatment(t =8.01,8.72,7.80,all P ＜ 0.05),and the differences were significant compared with the control group (t =7.57,8.34,7.29,all P ＜ 0.05).The TG,TC of blood lipid indexes indices after treatment of the observation group were (1.48 ±0.26) mmol/L,(5.18 ± 0.86)mmol/L,which were significantly lower than those before treatment (t =7.62,8.14,all P ＜ 0.05),and the differences were significant compared with the control group (t =7.10,7.55,all P ＜ 0.05).Conclusion The combination of silybin and nucleotides in the treatment of viral hepatitis with NAFLD has significant effect,can significantly improve the clinical symptoms and liver function indicators,and gradually restore the level of blood lipids,it is worthy of promoting the application.

Knowledge, attitude and practices concerning Hepatitis B infection, among healthcare workers in Bantama, Ghana: a cross sectional study.

Background: Hepatitis B is a serious, global, public health problem that gives rise to hepatocellular carcinoma / liver cancer with a mortality rate of about 600000 people, worldwide. Despite increasing prevalence of HBV and health care workers (HCWs) being at high risk for HBV, there is paucity of information on knowledge, attitude and practice (KAP) concerning HBV among HCWs, especially among developing countries like Ghana. Improved HBV related knowledge is imperative for developing an informed positive environment which can import, support and maintain HVB control good practices. Methods: This quantitative cross-sectional study aimed to evaluate KAP of HCWs was undertaken amongst 175 HCWs of Suntreso Government Hospital, Ghana. KAP regarding HBV were assessed using a standardized structured questionnaire. Descriptive statistics for patients’ demographic characteristics and mean scores for knowledge, attitude and practice of HCWs were applied. To establish association between study variables, Kruskal Wallis test and to assess the association between the KAP scores, Spearman’s rho correlation were used. Results: Mean scores for KAP were 13.691±2.81, 6.685±2.28 and 2.23±1.19 respectively. Age, occupation and experience were significantly associated with mean knowledge scores (p<0.05). Spearman rank correlation revealed significant positive correlations between knowledge-attitude (r = 0.539, p < 0.01), knowledge-practice (r = 0.388, p < 0.01) and attitude-practice (r = 0.458, p < 0.01). Conclusions: The study highlighted non-optimal KAP with regards to several aspects of HBV. Hence, there arises a need for policy guidelines along with extensive health education campaigns to manage all aspects of KAP of HCWs regarding HBV.

Clinical Characters Analysis of Patients with Drug-induced Liver Injury Combined with Hepatitis B / 中国药师

Objective:To analyze the clinical features of the patients with drug-induced liver injury ( DILI) combined with hepati-tis B to improve the awareness and attention to the disease by medical workers. Methods:Using retrospective analysis, the patients di-agnosed with DILI combined with hepatitis B from a tertiary-hospital were analyzed from January 2013 to January 2014. Results:Total-ly 30 cases of DILI combined with hepatitis B were collected, the number of male patients was higher than that of female patients, and most of them were elderly patients. The symptoms included weak, anorexia, yellow skin and sclera, tired of the oil, nausea, abdominal distension and so on. The patients with severe liver damage accounted for 80. 0%, 16. 7% was with moderate liver damage, and 3. 3%was with mild liver damage. Thirteen cases were mixed type, ten cases were hepatocellular type, and seven cases were cholestatic type. Conclusion:Middle-aged men may be prone to the disease, and the clinical manifestations are complex and diverse. Severe liver damage is majority, and often shows as mixed liver injury.

Serological response infected with on cynomolgus monkeys / 中国免疫学杂志

Objective:To study the serological reactions in cynomolgus monkeys infected with hepatitis B virus ( HBV). Methods:To select 1 to 3 days old or adult healthy cynomolgus monkeys by artificial breeding to observe the virology screening in laboratory a month to confirmed healthy animals ,randomly divided into control group and infection group .Infection group vaccination serum HBV carriers 0.5 ml (HBV-DNA≥108 copies) single cages,observe each group behavioral changes daily after inoculation 1 to 12 weeks, each week to confirmed the degree of liver inflammation through the HBV-M, HBV-DNA, liver function and on the B-guided, liver tissue inflammation by routine HE staining .Results: Adult monkeys did not induce positive reaction after vaccination , there were three young monkeys appear HBsAg , HBcAb and 2 appear HBV-DNA reaction, ALT poison attack occurred in HBsAg-positive began to increase after one week , one month after the peak , which was 180 U/L, after gradually decreased , continuing a month later near normal .AST higher than a week after the normal reference values were flat curve , representing the peak ALT after a month later, HBsAg positive cynomolgus monkeys HE staining showed mild hepatitis partial liver tissue lesions .Conclusion:HBV-M, HBV-DNA, ALT, AST and liver histopathology after HBV infection have changed , this result showing that it's produce inflammation and induction the response of immune .

Research on the oral nucleoside analogues monotherapy in the prevention of hepatitis B recurrence of patients after liver transplantation / 器官移植

Objective To explore the efficacy and safety of the oralnucle osideanalogues monotherapy in the prevention of hepatitis B recurrence of patients after liver transplantation (LT). Methods Clinical data of 32 patients with hepatitis B-related disease undergoing LT in the First People's Hospital of Foshan in Guangdong Province from October 1999 to April 2014 were retrospectively analyzed. The patients were divided into two phase groups according to the source of donors. Phase 1 was from October 1999 to September 2007 when 6 patients receiving LT of non-heart-beating donors. The serum hepatitis B virus (HBV) markers of 6 donor livers were all negative. The serum hepatitis B surface antigen (HBsAg)and hepatitis B core antibody (anti-HBc)of the recipients before operation were all positive,including 2 cases combined with Hepatitis Be antigen (HBeAg ) positive,1 case combined with hepatitis B viruse antibody (anti-HBe )positive. The serum HBV deoxyribonucleic acid (DNA)of 5 recipients before LT were over 1000 copies/ml and 1 case were below 1000 copies/ml. All the patients in phase 1 group were given lamivudine (100mg/d) monotherapy orally for the prevention of hepatitis B recurrence after LT. Phase 2 was from November 2011 to April 2014 when 26 patients receiving LT of donation after cardiac death including 1 case of combined liver-kidney transplantation. Six of the donor livers were with serum HBsAg positive and 20 cases negative. Fifteen cases were with hepatitis B surface antibody (anti-HBs)positive and 2 cases with HBeAg positive,14 cases with anti-HBc positive and 5 with anti-HBe positive. The serum HBV DNA of 11 recipients before LT were over 500 copies/ml and 15 cases below 500 copies/ml. Twenty-five cases were given entecarvir 0.5 mg/d and 1 casetelbivudine 600mg/d monotherapy or all for the prevention of hepatitis Brecurrence.Results The median follow-up time of the recipients in group phase 1 was 104 months. The serum HBsAg and HBV DNA were both negative in all recipients and no hepatitis B recurrence was observed till now. The median follow-up time of the recipients in group phase 2 was 50 weeks. Twenty cases received donor livers of negative HBsAg,in which 1 case had transient positive HBsAg 39 weeks after LT and became negative later. The patient receiving combined liver-kidney transplantation suffered hepatitis B recurrence 28 weeks after LT but HBV DNA was observed negative. No hepatitis B recurrence was observed in the 15 cases receiving donor livers of positive anti-HBc. Six cases receiving donor livers of positive HBsAg failed to become negative HBsAg after LT. All the follow-up recipients survived. No HBV DNA replication was observed in the recipients after LT. No adverse reaction of related nucleoside analogues was observed.Conclusions It is effective and safe tousenucleoside analogues monotherapy for the prevention of hepatitis B recurrence in patients after LT.

Influence of combination therapy of lamivudine and IFN on IL-8 level in chronic hepatitis B patients / 中国基层医药

Objective To explore the influence of combination therapy of IFN and lamivudine on IL-8 level in chronic hepatitis B patients.Methods 58 patients with chronic hepatitis B were selected and divided into control group and experiment group randomly and evenly.Based on regular treatments,control group received treatment of lamivudine and experiment group received combination treatment of lamivudine and IFN alpha-1 b.Restoring rate of ALT,serum conversion rate of HBeAg/anti-HBe,conversion rate of HBV-DNA and mutation rate of YMDD were observed and compared between two groups.Serum level of IL-8 was observed before and after treatment in two groups.Results Compared with control group,serum conversion rate of HBeAg/anti-HBe significantly increased,mutation rate of YMDD significantly decreased in experiment group(P ＜ 0.05).Serum level of IL-8 in two groups significantly decreased after treatment,but more significant in experiment group compared with control group (P ＜ 0.05).Conclusion Combination therapy of lamivudine and IFN shows positive effects to chronic hepatitis B,mainly via inhibiting activities of HBV and decreasing status of inflammation.

Knowledge, attitude and practice on hepatitis B prevention among dental professionals in India

Aim: To obtain comprehensive information about the knowledge, attitude and practices towardshepatitis B infection by dental health care professionals, and their effort to prevent the transmissionamong the patients. Methods: A cross sectional survey conducted among 540 dental health careworkers in a dental college and private practitioners in and around Bhimavarm, India. A selfassessmentquestionnaire with queries on levels, namely knowledge and practices, and protectivemeasures to prevent transmission of hepatitis B was recorded and statistically analyzed. Results:Frequency distribution scores of knowledge, attitude and practice in relation to hepatitis B infectionrevealed that the faculty members, the students under training along with, nurses, hygienists andlab technicians were relatively aware of hepatitis B vaccination, precautions and principles dropletisolation procedures to prevent transmission of hepatitis B infection. Conclusions: The resultsshowed that the dental professionals had good knowledge and attitude regarding hepatitis B andits transmission, but that the infection control measures among the health care professionals aremoderately poor and an educational program on isolation precautions can further enhance theselevels and thereby, reducing the risk of infection transmission.

Factors Influencing Blood Donations and the Rational Use of Blood.

A multicentric quasi-experimental study was conducted in Delhi, from March 2007 to September 2007, on i) the factors which stimulate the donors to donate blood, ii) major barriers and myths associated with blood donation and iii) clinicians perception of the rational use of blood. The study design included a face-to-face survey, with a pre-tested questionnaire paper in two leading blood banks of Delhi and by relevant interviewers from the community and medical fraternity. The sample size was 240-blood donors from two different blood banks and the control group included 100 potential donors from community and 50 clinicians from various hospitals. The data generated was analyzed using excel sheet and Epi-Info software. The study revealed the factors which influence the blood donation included replacement credit and family/peer pressure. Regarding myths and barriers, among potential donors, about a quarter of them felt that it is time consuming, and 20% felt it could lead to sexual impairment or is not rewarding. A total of 10% were not aware about the blood donation while 15% said that donation time was inconvenient. Of the 50 clinicians, a quarter of them were not aware of the rational use of blood.

Vírus da hepatite B: avaliação da resposta sorológica à vacina em funcionários de limpeza de hospital-escola / Hepatitis B virus: serum response to vaccine in teaching hospital cleaners

A hepatite viral B constitui um dos mais importantes problemas de saúde pública em todos os continentes. O vírus da hepatite B se transmite por via parenteral e, sobretudo, por via sexual. O objetivo foi avaliar a população ativa dos funcionários de limpeza do hospital da Faculdade de Medicina de Botucatu-UNESP, que receberam esquema completo de vacinação contra a hepatite B, medir os níveis de anticorpo contra o AgHBs (anti-HBs) e avaliar a sua relação com as condições epidemiológicas gerais, de vida pessoal e profissional e de risco de infecção pelo vírus da hepatite B.

Viral hepatitis B is one of the major public health problems in all continents. The hepatitis-B virus is transmitted parenterally and mainly sexually. The objective of this study was to evaluate the population composing the active cleaning staff of the Botucatu School of Medicine Hospital - UNESP who had received a complete vaccination scheme against hepatitis B, to measure their levels of antibodies against AgHBs (anti-HBs) and to evaluate their relationship with general epidemiological conditions, personal and professional life conditions and risk of infection by the hepatitis-B virus.

Conocimientos del personal estomatológico sobre la prevención de enfermedades transmisibles: Pinar del Río, 2007 / What the Dentistry personnel knows on prevention of contagious diseases: Pinar del Río, 2007

El presente estudio es una investigación analítica de corte transversal, que se realiza para evaluar los conocimientos sobre la prevención de enfermedades con riesgo de transmisión en Estomatología de los estomatólogos y técnicas de atención estomatológica (TAE), en las diferentes clínicas estomatológicas de la Ciudad de Pinar del Río entre los meses de Enero-Junio del año 2007. El universo de estudio coincide con la muestra y estuvo constituido por 60 estomatólogos y 60 técnicas de atención estomatológica, a los mismos se les aplicó un cuestionario. Una vez recogida la información se creó una base de datos con el programa Microsoft Excel, como medida resumen para los datos cualitativos se utilizó el porcentaje. Para analizar las diferencias entre grupos, se empleó el estadígrafo Chi cuadrado. Los datos se procesaran por el programa de tablas dinámicas de la hoja de calculo Excel y por el paquete estadístico SPSS, versión 8.0 para Windows, concluyendo que los estomatólogos y técnicas tienen gran necesidad de conocimientos sobre prevención de la transmisión de enfermedades con riesgo de propagación en la consulta. La mayoría de los estomatólogos y técnicos tienen evaluación de regular en la aplicación de las medidas de protección. Es contrastante que los estomatólogos en el cuestionario aplicado responden adecuadamente a las preguntas realizadas, sin embargo al observar el desempeño no se comportan de igual manera.

The present study is an analytical cross sectional study aimed at assessing what the dentistry personnel knows about the disease prevention at risk of contagious as well as the techniques in the different dental clinics in Pinar del Rio city between January and June, 2007. Universe coincides with sample and it is comprised of 60 dentists and of 60 dental care techniques using the same questionnaire in both. A data base was created using Microsoft Excel Program and the percentage method was used as a measure for the qualitative data.In order to study the differences between groups the Chi-square test was used.Data were processed using the dynamic table program from the Excel sheet and the satistical package SPSS version 8.0 Windows, it was concluded that dentists and dental techniques need to know about the prevention of the contagious disease at risk of spread to the dental care office.Most dentists and techniques are evaluated as regular according to the use of the protection measures, noting that dentists give a proper answer to the questionnaire applied and a different behaviour in the daily practice.

Seroprevalence and risk factors for hepatitis B virus infection among general population in Northern India / Soroprevalência e fatores de risco para infecção pelo vírus da hepatite B na população geral do nordeste da Índia

BACKGROUND: Infection with hepatitis-B virus has been a significant cause of morbidity claiming more than a million lives every year. Epidemiological data reveals that there are 360 million carriers of hepatitis-B virus throughout the globe and 78 percent of the world populations’ hail from Asia. Though several studies from Indian sub-continent have provided an estimate of the prevalence of this viral infection, there exist only few studies, which reflect the status in the general population. AIM: The present study was designed to investigate the prevalence of hepatitis-B infection in North Indian general population. METHODS: The study population comprised of 20,000 healthy blood donors who were screened for hepatitis-B surface antigen (HBsAg) status using third generation ELISA kit. Seroprevalence rate of seropositive donors was calculated and stratified by age, sex and blood groups. Statistical analysis was performed using tests of proportions, chi-square and confidence interval. RESULTS: The study showed that out of 20,000 donors, 450 (2.25 percent) were HBsAg positive (95 percent confidence interval (CI), 2.0445-2.4554). Higher prevalence of HbsAg was found among males (440/19235) than females (10/765). The age specific prevalence rose from 1.78 percent (108/6058) in donors aged 19-25 years to a maximum of 3.03 percent (96/3161) in donors aged 35-45 years and decreased in older age groups. The peaks were detected in male donors aged 35-45 years and in females aged 25-35 years. Rh-negative blood group donors (21/873) and Rh-positive group donors (429/19127) had almost equivalent prevalence rates of HBsAg. HBsAg was more prevalent in blood group B donors (174/7426) and less prevalent in AB blood group donors (38/2032). CONCLUSION: It was found that variables including gender and age were significantly associated with HBsAg positivity. HBsAg positivity in our population was statistically not associated with ABO blood groups.

RACIONAL: A infecção pelo vírus B da hepatite é considerada uma significante causa de morbidade, responsável por mais de 1 milhão de casos, a cada ano. Dados epidemiológicos revelam que existem 360 milhões de portadores de vírus da hepatite B no mundo e 78 por cento da população natural da Ásia. Embora vários estudos realizados na Ásia sub-continental tenham fornecido uma estimativa de prevalência desta infecção viral, existem poucos estudos que avaliam esta condição na população geral. OBJETIVO: Investigar a prevalência da infecção pelo víirus B da hepatite na população geral do nordeste da Índia. MÉTODOS: A população estudada compunha-se de 20.000 doadores de sangue sadios, selecionados através de positividade do antígeno de superfície da hepatite B (HBsAg), utilizando-se o kit ELISA de 3ª geração. A taxa de soroprevalência dos doadores soropositivos foi calculada e estratificada por idade, sexo e grupos sangüíneos. Análise estatística foi obtida usando-se testes de proporções, do qui ao quadrado e intervalo de confiança (CI). RESULTADOS: O estudo revelou que dos 20.000 doadores, 450 (2,25 por cento) eram HBsAg positivos (95 por cento CI 2.0445-2.4554). Prevalência maior de HBsAg foi encontrada em homens (440/19235) do que em mulheres (10/765). A prevalência por faixa etária aumentou de 1,78 por cento (108/6058) em doadores entre 19 a 25 anos, para máximo de 3,03 por cento (96/3161) naqueles entre 35-45 anos e decresceu nos grupos de maior idade. Os picos foram detectados em doadores masculinos de 35-45 anos e em mulheres de 25-35 anos. O grupo de doadores Rh negativo (21/873) e o grupo Rh positivo (4299/19127) mostraram taxas de prevalência de HBsAg quase equivalentes. HBsAg foi mais prevalente no grupo de doadores de tipo sangüíneo B (174/7426) e menos no grupo de tipo sangüíneo AB (38/2032). CONCLUSÃO: Verificou-se que variáveis incluindo gênero e idade foram significantemente associadas à positividade do HBsAg e que esta não foi...

Ganle Infusion Treat Hepatitis-B of Depressed Liver and Deficient Spleen Type / 浙江中医药大学学报

[Objective] To study the cure effect of Ganle Infusion on hepatitis-B of depressed liver and deficient spleen type.[Method] Randomly divide 60 cases into treatment group(Ganle Infusion) and control group(Diammonium Glycyrrhizinate capsule),observe concerned indexes change and clinical effects.[Result] For treatment group,the cure effect index was 93.3%;66.7% for control one;on liver improvement and serum hepatitis-B virus index negative-transfer rates,the treatment group was better than control one,with marked difference.[Conclusion] Ganle Infusion has marked cure effect on chronic hepatitis-B of the said type.

Serum Levels of Helper T Cell 1/Helper T Cell 2 Cytokines in Children with Hepatitis B Virus-Associated Glomerulonephritis and Its Clinical Significance / 实用儿科临床杂志

Objective To investigate the significance of helper T cell 1(Th1)/Th2 cytokines unbalance in children with hepatitis B virus-associated glomerulonephritis(HBV-GN).Methods The serum levels of interferon-gamma(IFN-?),interleukin-2(IL-2) and IL-4 were determined in 22 children with HBV-GN and 18 children with HBV by enzyme-linked immunosorbent assay(ELISA),respectively,and the difference of Th1/Th2 cytokines in the 2 groups.Results Serum levels of IL-2 and IFN-? in children with HBV-GN were decreased(P

Application of Microwave-ELISA Two-Step-Test to Hepatitis-B signs check in factory physical examination / 医疗卫生装备

Purpose:To Explore the requirements and accuracy for applying Microwave-ELISA Two-Steps-Test to the factory physical examination.Methods:Do the Microwave-ELISA Two-Steps-Test for 1,128 factory physical examination specimens that need the HBsAg and HBeAg inspection;comparing the result to the conventional ELISA test;and retest the specimens with the HBsAg-positive results.Results:There are 119 HBsAg-positive and 32 HBeAg-positive results for the ELISA test;there are 122 HBsAg-positive and 34 HBeAg-positive results for the microwave test;all the HBsAg-positive results are proved to be positive by using the colloid gold HbsAg rapid testing paper.Conclusion:Microwave-ELISA Two-Steps-Test is timesaving,simple and high sensitive for testing Hepatitis-B signs,which can reduce the hook phenomenon and can be used to do the large number of HBsAg and HBeAg checks in factory physical examinations.It can hasten the result report and greatly improve the efficiency.

Meta-analysis of document on diammonium Glycyrrhizinate in treatment of patients with chronic hepatitis B / 中华传染病杂志

Objective In order to evaluate the efficacy of Diammonium Glycyrrhizinate in the treatment of chronic hepatitis B. Methods The randomized clinical trials(RCTs) that compared the efficacy of Diammonium Glycyrrhizinate and other kind of treatment in chronic hepatitis-B were chosen from CBM disks from 1995 to 2004 and CNKI from 1995 to 2004.A meta-analysis was employed to evaluate the results of these therapies. Results Twenty-four RCTs including 3201 cases were analyzed.Compared with control group,the total RR of efficiency rate of Diammonium Glycyrrhizinate group were 1.378(95%CI 1.243～1.529),showing significant difference(P

The Comparison of Adverse Effect and Short-term Effect of Different Dosage of Recombinant Interferon Alpha-2b Treatment in Patients with Chronic Active Hepatitis Type B / 대한간학회지

BACKGROUND/AIMS: The efficacy and adverse effects of two different dosages of recombinant a2b interferon were studied in 45 patients with chronic active hepatitis B from March 1991 to December 1996. METHODS: The 19 patients received in a dose of 3MU thrice weekly for 16 weeks, the 14 patients received in a dose of 5MU thrice weeldy for 16 weeks and the 12 patients received conservative management. We evaluated serologic examination and adverse effects. Results 1) The rate of improvement in aminotransferase was significantly higher in interferon treated group (75.0%) compared to control group (16.7%) and it tended to be higher in 5MU group (85.6%) than 3MU group (68.4%) but, the latter had no statistical signifcance (P=0.27). 2) The disappearance rate of HBV-DNA was significantly higher in interferon treated group (72.7%) compared to control group (0%) and it tend to be higher in 3MU group (78.5%) than 5MU group (62.5%) but, the latter had no stastical significance (P=037). 3) The loss rate of HBeAg was significantly higher in interferon treated group (50.0%) compared to control group (O%) and it tend to be higher in 5MU group (66.7%) than 3MU group (37.5%) but, the latter had no stastical significance(P=0.13). 4) Fever (75.8%), leukopenia (41.2%), headache (30.3%), myalgia (18.2%), thrombocytopenia (17.6%), anorexia (11.8%) were noted and fever was significantly higher in 5MU group compared to 3MU group (P=0.02). Conclusion The effective improvement of liver function test and disappearance rate of HBeAg tended to be higher in 5MU group than 3MU group, but it was not stastistically significant. Fever was significantly higher in 5MU group compared to 3MU group.

Clinical experimental research on the treatment of chronic hepatitis-B with the combination of jiudaiqingyuan oral solution and lamivudine / 中国免疫学杂志

Objective:To explore the effect of jiudaiqingyuan oral solution in the treatment of chronic hepatitis-B(CHB) and in the elimination of HBV when used alone and combined with lamivudine.Methods:108 CHB patients were randomly divided into three groups:treatment group with Jiudaiqingyuan Oral Solution (Jiudai group),Lamivudine treatment group (lamivudine group),and treatment group with the combination of Jiudaiqingyuan Oral Solution and lamivudine (combination group),with each group including 36 cases.Laboratory tests were done before treatment,3,6,9 and 12 months after treatment,and at the 3rd,6th and 12th month of follow-up.The laboratory tests consisted of ALT,HBV-M and HBV-DNA.Results:At the 12th month of treatment and 12th month of follow-up,cases with normal ALT conversion cases with negative HBV-DNA conversion,cases with negative HBeAg conversion,HBeAg/anti-HBe serum conversion rate,and total effective rate of the combination group were respectively 94.4%,86.1%,55.6%,52.8%,75.0% and 83.3%,72.2%,47.2%,47.2%,72.2%,which were markedly better than those of Jiudai group or lamivudine group,with significant statistc difference in each index (P

EVALUATION OF DIAGNOSTIC SIGNIFICANCE OF ANTI-HBc IgM IN SUBCLINICAL HEPATITIS B INFECTION / 解放军医学杂志

The results of detection for anti-HBc IgM in 6 acute hepatitis B cases and a group of individuals with subclinical infection in an epidemic of HB were reported in this paper. The authors had followed up 5 children with subclinical HB infection for 6-7 months and found that the anti-HBc IgM in their sera became negative or declined while anti-HBs became positive. The results showed that the marker of anti-HBc IgM could be used as an indicator of recent subclinical HB infection. This result is valuable in epide-miological survey of HB in general population. The geometric mean values (GMV) of S/N of anti-HBc IgM during the "window period" and the period of seroconversion to anti-HBs in subclinical infection were 3.9 and 1.9, respectively, and were lower than in clinical infection (6.9 and 7.4, respectively). Furthermore, the duration of that was shorter. The phenomenon is worthy of studying further. During the early convalescence, i. e., the period of seroconversion to anti-HBs in patients with acute hepatitis B, the GMV of S/N of anti-HBc IgM was high up to 7.4, which indicated that they might also be infectious.